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A mechanism of latent cryoinjury and reparation of mitochondria.

Author(s) : PETRENKO A. Ju.

Type of article: Article

Summary

Changes in the systems of oxidative phosphorylation and ion transport of rat liver mitrochondria have been studied during storage or incubation after freeze-thawing. It has been found that two different processes take place in frozen-thawed mitochondria. The latent cryoinjury appears as a result of oxidation of endogenous pyridine nucleotides under conditions of high permeability of the inner membrane and low membrane potential, thus causing activation of the membrane lipid peroxidation and enzyme hydrolysis, leakage of cations, and deenergization of mitochondria. Inhibition of the latent cryoinjury favours the restoration of mitochondrial function after freeze-thawing.

Details

  • Original title: A mechanism of latent cryoinjury and reparation of mitochondria.
  • Record ID : 1993-0532
  • Languages: English
  • Source: Cryobiology - vol. 29 - n. 1
  • Publication date: 1992/02

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