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Effets de l'Hypothermosol, une solution expérimentale acellulaire, pour la conservation des tissus et dans les interventions impliquant une circulation extra-corporelle, effectuées sur des vaisseaux coronaires d'agneau isolés et soumis à des conditions d'hypothermie et d'anoxie extrêmes.

Effects of Hypothermosol, an experimental acellular solution for tissue preservation and cardiopulmonary bypass, on isolated newborn lamb coronary vessels subjected to ultra profound hypothermia and anoxia.

Auteurs : DAHDAH N. S., TAYLOR M. J., RUSSO P., et al.

Type d'article : Article

Résumé

Ultra profound hypothermia (4 to 10 °C) is an experimental method aiming at safely prolonging organ and total body preservation. For this purpose, Hypothermosol (HTS), an investigational acellular solution for blood substitution, was demonstrated to be beneficial in animal models undergoing cardiopulmonary bypass. The authors investigated the beneficial versus deleterious effects of cold preservation and the role of HTS on isolated coronary arteries (CA) during cold exposure, rewarming, and post-rewarming exposure to anoxia. Newborn lamb CA rings were studied using a tissue bath technique. CA were subjected to cold (7 °C for 3 hours) and treated with either Krebs' buffer (Krebs/ hypothermia) or HTS (HTS/hypothermia) (n= 15 each). A third group maintained at 37 °C (Krebs/ normothermia) (n= 18) served as a time control. This study demonstrated that ultra profound hypothermia promotes coronary vasoconstriction upon rewarming, which is detrimental to relaxant response to hypoxia. Both phenomena are alleviated by performing ultra profound hypothermia under HTS protection.

Détails

  • Titre original : Effects of Hypothermosol, an experimental acellular solution for tissue preservation and cardiopulmonary bypass, on isolated newborn lamb coronary vessels subjected to ultra profound hypothermia and anoxia.
  • Identifiant de la fiche : 2000-2228
  • Langues : Anglais
  • Source : Cryobiology - vol. 39 - n. 1
  • Date d'édition : 08/1999

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