Partager

Effets paradoxaux de la température sur le tonus vasculaire.

Paradoxical effects of temperature on vascular tone.

Auteurs : HERRERA B., EISENBERG G., HOLBERNDT O., et al.

Type d'article : Article

Résumé

Temperature may have significant influence on vascular tone in contexts such as organ preservation, coronary bypass surgery, and extracorporeal circulation. The direct effect of temperature variation on vascular tone was studied in an attempt to elucidate the mechanisms involved. In a first series of experiments, the isometric tension of two vessels (rat thoracic aorta and pig renal branch artery) was studied at different temperatures. To study the role of calcium in this response, a second series of experiments was performed: vessels were incubated with the intracellular chelator BAPTA/AM. Further experiments were performed to test the effect of cold storage. Results show that changes in temperature lead to different results in pig renal artery and rat aorta. A decrease in temperature induced highly reproducible relaxation in rat aorta, whereas pig renal artery presented cooling-induced contraction. Moreover, calcium depletion failed to inhibit cooling-induced relaxation in rat aorta, but did not provoke cooling-induced contraction in pig renal artery. Similar responses were obtained with cold storage and calcium depletion. Structural factors thus appear to be involved.

Détails

  • Titre original : Paradoxical effects of temperature on vascular tone.
  • Identifiant de la fiche : 2001-2954
  • Langues : Anglais
  • Source : Cryobiology - vol. 41 - n. 1
  • Date d'édition : 08/2000

Liens


Voir d'autres articles du même numéro (3)
Voir la source

Indexation