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Cryoconservation de lymphocytes humains.

[In Japanese. / En japonais.]

Auteurs : HOMMA T., MORIMOTO C.

Type d'article : Article

Résumé

Studies of cryopreservation of bone marrow cells and peripheral blood stem cells required for autologus bone marrow transplantation or peripheral blood stem cell transplantation have resulted in simple and reliable methods over the past 35 years. Current cryopreservation procedures have little effect on viability and responsiveness to mitogens of human peripheral blood lymphocytes. While some functional activities of human peripheral blood lymphocytes are reduced by cryopreservation, short-term culture restores these activities. It has recently been demonstrated that in vitro culture of peripheral blood lymphocytes from patients infected with a human immunodeficiency virus, the presence of certain mitogenic stimuli eliminates the virus from the cells. Development of an immunological treatment based on large-scale culture and cryopreservation of human peripheral blood lymphocytes is under investigation.

Détails

  • Titre original : [In Japanese. / En japonais.]
  • Identifiant de la fiche : 1999-0583
  • Langues : Japonais
  • Source : Low Temperature Medicine - vol. 23 - n. 3
  • Date d'édition : 09/1997
  • Document disponible en consultation à la bibliothèque du siège de l'IIF uniquement.

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