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Cryopreservation of human lymphocytes.

[In Japanese. / En japonais.]

Author(s) : HOMMA T., MORIMOTO C.

Type of article: Article

Summary

Studies of cryopreservation of bone marrow cells and peripheral blood stem cells required for autologus bone marrow transplantation or peripheral blood stem cell transplantation have resulted in simple and reliable methods over the past 35 years. Current cryopreservation procedures have little effect on viability and responsiveness to mitogens of human peripheral blood lymphocytes. While some functional activities of human peripheral blood lymphocytes are reduced by cryopreservation, short-term culture restores these activities. It has recently been demonstrated that in vitro culture of peripheral blood lymphocytes from patients infected with a human immunodeficiency virus, the presence of certain mitogenic stimuli eliminates the virus from the cells. Development of an immunological treatment based on large-scale culture and cryopreservation of human peripheral blood lymphocytes is under investigation.

Details

  • Original title: [In Japanese. / En japonais.]
  • Record ID : 1999-0583
  • Languages: Japanese
  • Source: Low Temperature Medicine - vol. 23 - n. 3
  • Publication date: 1997/09
  • Document available for consultation in the library of the IIR headquarters only.

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