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Efficacité de la trimétazidine dans le dysfonctionnement rénal consécutif à l'altération de reperfusion-ischemie due au froid : un complément à la solution proposée par l'Université du Wisconsin.

Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution.

Auteurs : HAUET T., TALLINEAU C., GOUJON J. M., CARRETIER M., EUGENE M., TILLEMENT J. P.

Type d'article : Article

Résumé

The addition of trimetazidine (TMZ) to the University of Wisconsin solution (UW) improved dramatically the quality of preserved kidneys and consequently the functional recovery during reperfusion. TMZ + UW also significantly had a protecting role against reperfusion injury and lipid peroxidation when compared to UW alone. These results were correlated with both a better preservation of the proximal brush border membrane and reduced cellular and mitochondrial swelling. These results also suggested that the TMZ-induced renoprotection correlated well with the observed decrease membrane lipid peroxidation. Therefore, trimetazidine may be useful for clinical kidney graft preservation.

Détails

  • Titre original : Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution.
  • Identifiant de la fiche : 1999-3913
  • Langues : Anglais
  • Source : Cryobiology - vol. 37 - n. 3
  • Date d'édition : 11/1998

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