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Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution.

Author(s) : HAUET T., TALLINEAU C., GOUJON J. M., CARRETIER M., EUGENE M., TILLEMENT J. P.

Type of article: Article

Summary

The addition of trimetazidine (TMZ) to the University of Wisconsin solution (UW) improved dramatically the quality of preserved kidneys and consequently the functional recovery during reperfusion. TMZ + UW also significantly had a protecting role against reperfusion injury and lipid peroxidation when compared to UW alone. These results were correlated with both a better preservation of the proximal brush border membrane and reduced cellular and mitochondrial swelling. These results also suggested that the TMZ-induced renoprotection correlated well with the observed decrease membrane lipid peroxidation. Therefore, trimetazidine may be useful for clinical kidney graft preservation.

Details

  • Original title: Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution.
  • Record ID : 1999-3913
  • Languages: English
  • Source: Cryobiology - vol. 37 - n. 3
  • Publication date: 1998/11

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