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Recherche sur la nucléation induite par ultrasons afin d’améliorer l’efficacité de la cryoablation.

Research on ultrasound-induced nucleation to improve cryoablation effectiveness.

Auteurs : LI W., YANG X., WANG Y., LIU B., YOUNAS S.

Type d'article : Article de la RIF

Résumé

This research proposes a novel combination therapy that utilizes ultrasound-assisted cryoablation to enhance the lethality of cryoablation in Hepatocellular Carcinoma (HepG2) cells. Ultrasound is used to induce ice nucleation, followed by thawing at a set temperature. The efficacy of this approach was evaluated by assessing cell survival rates in hepatocellular carcinoma cells using Acridine Orange/ Propidium Iodide (AO/PI) staining and the Cell Counting Kit-8 (CCK-8), comparing ultrasound-assisted cryoablation with cryoablation alone. At a cooling rate of 10 °C/min and lower nucleation temperatures, a significant reduction in cell survival rate was observed (15.60 ± 2.60 %). Cryomicroscopic observations revealed that enhanced intracellular and extracellular ice formation led to increased cellular damage and higher cryoablation lethality. This innovative therapy provides a promising approach for localized treatment and highlights the potential of cryoablation devices incorporating ultrasound-induced nucleation.

Documents disponibles

Format PDF

Pages : 489-499

Disponible

  • Prix public

    20 €

  • Prix membre*

    Gratuit

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Détails

  • Titre original : Research on ultrasound-induced nucleation to improve cryoablation effectiveness.
  • Identifiant de la fiche : 30033494
  • Langues : Anglais
  • Source : International Journal of Refrigeration - Revue Internationale du Froid - vol. 170
  • Date d'édition : 02/2025
  • DOI : http://dx.doi.org/10.1016/j.ijrefrig.2024.12.011

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