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Cryoconservation bio-inspirée fondée sur des analogues de type polymère synthétique.

Bio-inspired cryopreservation using synthetic polymer analogues.

Numéro : pap. 003

Auteurs : BAILEY T. L., OTTEN L. C., GIBSON M. I.

Résumé

With an ever-ageing population in the Western world, the need for regenerative medicine, especially transplantation is increasing, but the number of donors remains static. Therefore improved storage methods for cells/tissues/organs is urgently required to overcome their limited shelf life. This is also a challenge in fundamental biology, where the cryostorage of many cell types is still not possible, or leads to sub-standard performance of the cells. Antifreeze glycoproteins (AFGPs) from polar fish, slow ice crystal growth and may find application in cryopreservation, but are limited by their extremely high costs, challenging synthesis, and potential toxicity. To address this, we have developed synthetic polymers, which can reproduce the desirable properties of AFGPs, without the side effects, at lower cost. Here I will discuss our efforts to rationally design new AFGP mimetic materials using both synthetic and biological methods, and their application to enhance cell storage.

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Format PDF

Pages : 4 p.

Disponible

  • Prix public

    20 €

  • Prix membre*

    Gratuit

* meilleur tarif applicable selon le type d'adhésion (voir le détail des avantages des adhésions individuelles et collectives)

Détails

  • Titre original : Bio-inspired cryopreservation using synthetic polymer analogues.
  • Identifiant de la fiche : 30019492
  • Langues : Anglais
  • Source : 2nd IIR Workshop on cold applications in life sciences.
  • Date d'édition : 08/09/2016
  • DOI : http://dx.doi.org/10.18462/iir.cals.2016.0003

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