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Greffes réussies d'îlots pancréatiques humains dans des souris nues diabétiques.

Successful engraftment of cryopreserved human pancreatic islets into diabetic nude mice.

Auteurs : KENMOCHI T., MARUYAMA M., MULLEN Y., et al.

Type d'article : Article

Résumé

For the purpose of the realization of clinical cryopreserved islet transplantation, frozen-thawed human islets were examined in vitro by static incubation and in vitro by transplantation models using diabetic nude mice. In a histological study, round and well-shaped-shape islets were detected beneath the kidney capsule, demonstrating good function of the frozen-thawed human islets. Cryopreservation is the most promising technique for long-term storage of human islets and has many advantages. From the results of the study, it was demonstrated that frozen-thawed human islets had an ability of insulin secretion and potential diabetes cure when enough islets were transplanted. In addition to fresh islet transplantation, frozen-thawed islet transplantation has great potential for clinical application.

Documents disponibles

Format PDF

Pages : 4-7

Disponible

  • Prix public

    20 €

  • Prix membre*

    15 €

* meilleur tarif applicable selon le type d'adhésion (voir le détail des avantages des adhésions individuelles et collectives)

Détails

  • Titre original : Successful engraftment of cryopreserved human pancreatic islets into diabetic nude mice.
  • Identifiant de la fiche : 2007-2322
  • Langues : Anglais
  • Source : Low Temperature Medicine - vol. 33 - n. 1
  • Date d'édition : 03/2007

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