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Successful engraftment of cryopreserved human pancreatic islets into diabetic nude mice.

Author(s) : KENMOCHI T., MARUYAMA M., MULLEN Y., et al.

Type of article: Article

Summary

For the purpose of the realization of clinical cryopreserved islet transplantation, frozen-thawed human islets were examined in vitro by static incubation and in vitro by transplantation models using diabetic nude mice. In a histological study, round and well-shaped-shape islets were detected beneath the kidney capsule, demonstrating good function of the frozen-thawed human islets. Cryopreservation is the most promising technique for long-term storage of human islets and has many advantages. From the results of the study, it was demonstrated that frozen-thawed human islets had an ability of insulin secretion and potential diabetes cure when enough islets were transplanted. In addition to fresh islet transplantation, frozen-thawed islet transplantation has great potential for clinical application.

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Pages: 4-7

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Details

  • Original title: Successful engraftment of cryopreserved human pancreatic islets into diabetic nude mice.
  • Record ID : 2007-2322
  • Languages: English
  • Source: Low Temperature Medicine - vol. 33 - n. 1
  • Publication date: 2007/03

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