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Lyophilisation des plaquettes sanguines humaines : influence du tréhalose et des protecteurs extracellulaires.

Freeze-drying of human platelets: influence of intracellular trehalose and extracellular protectants.

Auteurs : ZHOU X. L., ZHU H., ZHANG S. Z., et al.

Type d'article : Article

Résumé

The long-term preservation of human platelets in blood banks is difficult. The authors investigated freeze-drying. They used intracellular trehalose as lyoprotectant. Bovine serum albumin and trehalose were used as extracellular protectants. The results demonstrated that 13 mM intracellular trehalose exerted a beneficial effect on freeze-dried human platelets, and slighting improved the protection provided by extracellular protectants. The survival rate of rehydrated platelets was roughly 85%, the morphology was not affected and the aggregation percentage with thrombin (1 U/ml) was 97.3%.

Détails

  • Titre original : Freeze-drying of human platelets: influence of intracellular trehalose and extracellular protectants.
  • Identifiant de la fiche : 2006-2687
  • Langues : Anglais
  • Source : CryoLetters - vol. 27 - n. 1
  • Date d'édition : 01/2006

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