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Comportement des cellules dans une solution ternaire lors de la congélation : étude numérique.

A numerical study of cell behaviour in a ternary solution during the freezing process.

Auteurs : LUO D., HE L., CHENG S., et al.

Type d'article : Article

Résumé

Using a continuum model for multi-component phase change system, the freezing of cell suspension in a ternary solution, H2O-NaCl-CPA (cryoprotective agent) inside a flat bag was investigated numerically in this study. The temperature and phase change history, intracellular water loss, and the volume change of the cells at different locations inside cell suspension are calculated. Numerical results revealed that although the sample boundary was cooled at a constant rate, different locations inside the sample experienced different temperature changes and cooling rates. The highest cooling rates occurerd at internal locations. The cell volume change was location-dependent.

Détails

  • Titre original : A numerical study of cell behaviour in a ternary solution during the freezing process.
  • Identifiant de la fiche : 2004-0410
  • Langues : Anglais
  • Source : CryoLetters - vol. 24 - n. 3
  • Date d'édition : 05/2003
  • Document disponible en consultation à la bibliothèque du siège de l'IIF uniquement.

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