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Développement de techniques optimales pour la cryoconservation des plaquettes humaines.

Development of optimal techniques for cryopreservation of human platelets.

Auteurs : GAO D. Y., NEFF K., XIAO H. Y., et al.

Résumé

Under present blood bank storage conditions at 22 °C, the viability and function of human platelets can be maintained for only 5 days, precluding use in many clinical contexts. Optimal techniques for platelet preservation studied by the authors were: use of cryoprotective agents (DMSO, ethylene glycol and propylene glycol) during storage at 22 and 8 °C. DMSO proved to be the optimal cryoprotectant. Future studies will focus on: optimal protocols for cryopreservation of human platelets, and identification of suitable calcium chelators and cytoskeleton stabilizers designed to prevent activation and preserve viability and function.

Détails

  • Titre original : Development of optimal techniques for cryopreservation of human platelets.
  • Identifiant de la fiche : 2000-2806
  • Langues : Anglais
  • Date d'édition : 05/1999
  • Source : Source : Cryobiology/Soc. Cryobiol., Annu. Meet., Pittsburgh/Symp. Cryopreserv. human Platelets, Pittsburgh
    vol. 38; n. 3; 225-235; 7 fig.; 31 ref.

Indexation