Development of optimal techniques for cryopreservation of human platelets.
Author(s) : GAO D. Y., NEFF K., XIAO H. Y., et al.
Summary
Under present blood bank storage conditions at 22 °C, the viability and function of human platelets can be maintained for only 5 days, precluding use in many clinical contexts. Optimal techniques for platelet preservation studied by the authors were: use of cryoprotective agents (DMSO, ethylene glycol and propylene glycol) during storage at 22 and 8 °C. DMSO proved to be the optimal cryoprotectant. Future studies will focus on: optimal protocols for cryopreservation of human platelets, and identification of suitable calcium chelators and cytoskeleton stabilizers designed to prevent activation and preserve viability and function.
Details
- Original title: Development of optimal techniques for cryopreservation of human platelets.
- Record ID : 2000-2806
- Languages: English
- Publication date: 1999/05
- Source: Source: Cryobiology/Soc. Cryobiol., Annu. Meet., Pittsburgh/Symp. Cryopreserv. human Platelets, Pittsburgh
vol. 38; n. 3; 225-235; 7 fig.; 31 ref.
Indexing
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MORPHOLOGICAL AND FUNCTIONAL DISTURBANCES OF PL...
- Author(s) : BAYTHOON H., TUDDENHAM E. G. D., HUTTON R. A.
- Date : 1982
- Languages : English
- Source: J. clin. Pathol. - vol. 35 - n. 8
View record
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ULTRASTRUCTURAL ALTERATIONS AND PHAGOCYTIC FUNC...
- Author(s) : SPECTOR J. I., FLOR W. J., VALERI C. R.
- Date : 1979
- Languages : English
- Source: Transfusion - vol. 19 - n. 3
View record
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LA CRYOCONSERVATION DES PLAQUETTES.
- Author(s) : LOPEZ M., ELGHOUZZI M. H.
- Date : 1980
- Languages : French
- Source: Rev. fr. Transfus. Immuno-Hématol. - vol. 23 - n. 6
View record
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Platelet cryopreservation using a combination o...
- Author(s) : XIAO H., HARVEY K., LABARRERE C. A., et al.
- Date : 2000/09
- Languages : English
- Source: Cryobiology - vol. 41 - n. 2
View record
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CIRCULATION AND FUNCTION OF HUMAN PLATELETS ISO...
- Author(s) : VECCHIONE J. J.
- Date : 1982
- Languages : English
- Source: Transfusion - vol. 22 - n. 3
View record