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Shape stabilizing agents protect erythrocytes against freeze-thaw damage.

Author(s) : BAKALTCHEVA I., RUDOLPH A. S., SPARGO B. J.

Type of article: Article

Summary

The authors demonstrate that physicochemical modification of the erythrocyte membrane by shape stabilizing agents increases cryostability. Three different classes of shape stabilizing agents were examined for their cryoprotective action: the lectins, sulfhydryl oxidizing agents and chemical fixatives. All classes of agents reduced freeze-thaw damage after freezing erythrocytes to -20 deg C in a concentration and time dependent manner. The ability to alter membrane deformability may not by itself result in shape stabilization or cryoprotection. The ability to stabilize red cells may however result in increased cryostability.

Details

  • Original title: Shape stabilizing agents protect erythrocytes against freeze-thaw damage.
  • Record ID : 1998-2564
  • Languages: English
  • Source: Cryo-Letters - vol. 18 - n. 3
  • Publication date: 1997/05
  • Document available for consultation in the library of the IIR headquarters only.

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