Share

STORAGE OF RED BLOOD CELLS AT 273 K (0 DEG C).

[In Japanese. / En japonais.]

Author(s) : YAMAMURA H., UDA M.

Type of article: Article

Summary

LOWERING THE STORAGE TEMPERATURE OF RED CELLS TO 273 K (0 DEG C) HAS SIGNIFICANT EFFECTS ON RED CELL GLYCOLYTIC METABOLISM INCLUDING LOWER GLUCOSE CONSUMPTION, REDUCED LACTATE PRODUCTION, AND HIGHER ATP AND 2, 3-DPG MAINTENANCE. THE STUDY WAS DESIGNED TO EVALUATE WHETHER RED CELLS CAN BE STORED SAFELY AT 273 K WITHOUT A MARKED LESION DUE TO THE EFFECT OF LOW TEMPERATURE. IRREVERSIBLE CHANGES, SUCH AS VESICLE FORMATION AND HEMOLYSIS OF THE RED CELLS WERE OBSERVED TO BE SLIGHTLY HIGHER AT 273 K AS COMPARED WITH THE RED CELLS STORED AT 278 K (5 DEG C) DURING THE FIRST 3 WEEKS. AFTER 6 WEEKS, HOWEVER, THESE VALUES FOR THE RED CELLS STORED AT 273 K WERE ABOUT 3 TIMES LESS THAN THOSE FOR THE RED CELLS STORED AT 278 K. THE RED CELLS STORED AT 273 K SHOWED MUCH HIGHER LEVELS OF MORPHOLOGY SCORE AND DEFORMABILITY INDEX, LOWER HEMOLYSIS AFTER WARMING AT 310 K (37 DEG C) FOR 24 HR, ADN LESS OSMOFRAGILITY IN COIL PLANET CENTRIFUGATION TEST THAN THE TE THAT RED CELLS ARE MUCH BETTER STORED AT 273 K.

Details

  • Original title: [In Japanese. / En japonais.]
  • Record ID : 1989-2522
  • Languages: Japanese
  • Source: Low Temperature Medicine - vol. 14 - n. 4
  • Publication date: 1988
  • Document available for consultation in the library of the IIR headquarters only.

Links


See other articles in this issue (1)
See the source

Indexing