ShareAdvances in brain tissue cryopreservation
A team of researchers has developed a method for preserving the neuronal architecture and functional activity of cerebral organoids. This could make it possible to reduce the long-term costs of culturing these tissues.
Human brain tissue models and organoids are essential for the study and modeling of human neurological diseases, but their long-term culture is expensive and limits their application.
A team of researchers from Fudan University in China has developed a method called MEDY. It uses methylcellulose, ethylene glycol, DMSO and Y27632.
According to their research published last May in Cell Reports Methods (doi: 10.1016/j.crmeth.2024.100777), this method would make it possible to preserve the structure and functional activity of cortical organoids.
The researchers also carried out tests on human brain tissue: these showed that the pathological characteristics of the samples were preserved after thawing. This development could open new avenues in biomedical research.
Did you know?
An IIR working group is dedicated to whole-body cryotherapy. [More information]
An Information Note has been written on this subject. [Download in FRIDOC]