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COLD SHOCK -A WIDESPREAD CELLULAR REACTION.

Author(s) : MORRIS G. J.

Type of article: Article

Summary

THE RESPONSE TO RAPID COOLING TO SUB-ZERO TEMPERATURES IN THE ABSENCE OF ICE FORMATION OF A VARIETY OF CELL-TYPES WAS EXAMINED. WITH TETRAHYMENA PYRIFORMIS, THALASSIOSIRA WEISSFLOGII, CHLAMYDOMONAS REINHARDII, SYCAMORE SUSPENSION CULTURES, ISOLATED MAMMALIAN HEPATOCYTES AND HUMAN LYMPHOID CELL LINE CELLS A SIGNIFICANT REDUCTION IN VIABILITY WAS OBSERVED FOLLOWING THIS STRESS. BY CONTRAST, HUMAN ERYTHROCYTES WERE NOT HAEMOLYSED BY RAPID COOLING, EVEN TO 263 K (-10 DEG C), UNLESS THE CELLS WERE PRE-SENSITISED BY EXPOSURE TO HYPERTONIC SODIUM CHLORIDE. IT IS APPARENT THAT INJURY INDUCED BY COLD SHOCK IS A MORE WIDESPREAD CELLULAR REACTION THAN HAS PREVIOUSLY BEEN CONSIDERED.

Details

  • Original title: COLD SHOCK -A WIDESPREAD CELLULAR REACTION.
  • Record ID : 1984-2116
  • Languages: English
  • Source: Cryo-Letters - vol. 4 - n. 3
  • Publication date: 1983
  • Document available for consultation in the library of the IIR headquarters only.

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