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CRYOANALGESIA: THE RESPONSE TO ALTERATIONS IN FREEZE CYCLE AND TEMPERATURE.

Author(s) : EVANS P. J. D., LLOYD J. W., GREEN C. J.

Type of article: Article

Summary

ONE HUNDRED AND FORTY MALE RATS RECEIVED A CRYOINJURY TO A SEGMENT OF THE EXPOSED SCIATIC NERVE. WHERE OBVIOUS NERVE FREEZING OCCURRED, THE CRYOINJURY CAUSED COMPLETE LOSS OF FUNCTION IN THE LIMB. THE RETURN OF MOTOR ACTIVITY WAS FIRST NOTED AT 25 DAYS (MEAN) BUT COMPLETE RETURN OF MOTOR ACTIVITY AND OF PAIN SENSATION WAS NOTED AFTER 38 DAYS (MEAN). THE TIME TAKEN FOR REGENERATION WAS INDEPENDENT OF BOTH THE DURATION OF FREEZING AND THE APPLICATION OF A REPEAT FREEZE CYCLE. THE TEMPERATURE ATTAINED BY THE NERVE WAS, HOWEVER, IMPORTANT. WHERE IT REMAINED GREATER THAN 253 K (-20 DEG C) THE RESULTS WERE UNPREDICTABLE, BUT BELOW THIS TEMPERATURE THE INTERRUPTION WAS PROLONGED AND UNINFLUENCED BY GREATER REDUCTIONS IN TEMPERATURE.

Details

  • Original title: CRYOANALGESIA: THE RESPONSE TO ALTERATIONS IN FREEZE CYCLE AND TEMPERATURE.
  • Record ID : 1982-2105
  • Languages: English
  • Source: Br. J. Anaesth. - 53; 1121-1127; 2 fig.; 4 tabl.; 20 ref.
  • Publication date: 1981
  • Document available for consultation in the library of the IIR headquarters only.

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