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CRYOIMMUNOLOGICAL STUDY OF HUMAN BONE MARROW CELLS: VARIATION OF INTERLEUKIN 2. PRODUCTION POTENTIAL AFTER CRYOPRESERVATION.

Author(s) : LEI C. M.

Summary

THE AUTHORS STUDIED THE EFFECT OF FREEZING ON INTERLEUKIN 2 (I L2) PRODUCTION OF HUMAN BONE MARROW MONONUCLEAR CELLS. IT WAS FOUND THAT IL2 PRODUCED BY FROZEN MARROW CELLS WAS SEVERAL TIMES HIGHER THAN THAT OF FRESH ONES, AND IN APPROPRIATE DILUTIONS, IT COULD BE AS MANY AS 10 TIMES HIGHER. THE IL2 PRODUCTION WAS NOT AFFECTED BY THE LENGTH OF TIME WITHIN 5 WEEKS WHEN MARROW CELLS WERE PRESERVED AT 77 K (-196 DEG C). DMSO DEPRESSED THE IL2 PRODUCTION ABILITY. THE AUTHORS PUT FORWARD A HYPOTHESIS THAT THE ENHANCEMENT OF IL2 PRODUCTION POTENTIAL OF FROZEN MARROW CELLS MAY MAKE A CONTRIBUTION TO MARROW-TRANSPLANTED RECIPIENTS WHEN CRYOPRESERVED CELLS ARE USED, AND THAT THE INCREASE, IF TRUE FOR PERIPHERAL BLOOD LYMPHOCYTES, MAY EXPLAIN THE IMMUNOLOGICAL EFFECTS OF CRYOSURGERY TO SOME EXTENT.

Details

  • Original title: CRYOIMMUNOLOGICAL STUDY OF HUMAN BONE MARROW CELLS: VARIATION OF INTERLEUKIN 2. PRODUCTION POTENTIAL AFTER CRYOPRESERVATION.
  • Record ID : 1990-2622
  • Languages: English
  • Publication date: 1989/10/11
  • Source: Source: Proc. 7th int. Congr. Cryosurg., Beijing
    265-269; 1 fig.; 1 tabl.; 9 ref.
  • Document available for consultation in the library of the IIR headquarters only.

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