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Cryopreservation of red blood cells with the non-penetrating cryoprotectant hydroxyethyl starch.

Author(s) : SPUTTEK A., SINGBARTL G., LANGER R., SCHLEINZER W., HENRICH H. A., KUHNL P.

Type of article: Article

Summary

After promising results obtained in experiments with German shepherd dogs (n = 6,400 millilitres of whole blood were replaced by frozen/thawed red blood cells without any postthaw treatment), initial autologous studies were carried out on 7 healthy volunteers. The retransfusion of cryopreserved autologous red blood cells was performed without any postthaw washing step. In all 7 cases the frozen/thawed autologous red blood cells were tolerated very well. The level of free plasma hemoglobin increased initially by a factor of 2, and then decreased to normal levels within 20 hours. More than 85% of the hydroxyethyl starch was eliminated from the plasma within the first day.

Details

  • Original title: Cryopreservation of red blood cells with the non-penetrating cryoprotectant hydroxyethyl starch.
  • Record ID : 1996-2565
  • Languages: English
  • Source: Cryo-Letters - vol. 16 - n. 5
  • Publication date: 1995/09
  • Document available for consultation in the library of the IIR headquarters only.

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