Share

Cryosurgery of Dunning AT-1 rat prostate tumour: thermal, biophysical and viability response at the cellular and tissue level.

Author(s) : BISCHOF J. C., SMITH D., PAZHAYANNUR P. V., MANIVEL C., HULBERT J., ROBERTS K. P.

Type of article: Article

Summary

The thermal history around a 3-millimeter diameter cylindrical cryosurgical probe was predicted by solving the bioheat equation in a one-dimensional cylindrical geometry. These cooling rates and end-temperatures were then imposed on single AT-1 cells, AT-1 tissue slices in vitro and AT-1 tumours in vivo. Based solely on the single cell and in vitro tissue damage achieved by cooling rates and end-temperatures, a sizable portion of a cryosurgically frozen tumour would be expected to survive. However, in vivo cryosurgery performed on AT-1 tumours demonstrated that the tissue was damaged throughout the cryolesion, event at the periphery where the thermal history would be expected to allow single cells and tissue slices to survive in vitro. Taken together, the results suggest that damage mechanisms other than those due to cooling rate and end-temperature may be responsible for the increased cellular destruction at the periphery of the iceball in vivo and that cooling rate is less important than end-temperature in determining cryosurgical damage in AT-1 tumours.

Details

  • Original title: Cryosurgery of Dunning AT-1 rat prostate tumour: thermal, biophysical and viability response at the cellular and tissue level.
  • Record ID : 1998-1310
  • Languages: English
  • Source: Cryobiology - vol. 34 - n. 1
  • Publication date: 1997/02

Links


See other articles in this issue (5)
See the source

Indexing