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Effect of formulation on stability of freeze-dried recombinant human alpha interferon.

Author(s) : MOREIRA T., BARBERIA D., GUTIERREZ A., VEGA M., PUJOL V., SOTOLONGO J., DUQUE J., POMES R.

Type of article: Article

Summary

The authors study the influence of two formulations on the stability of freeze-dried recombinant human alpha interferon and on the crystallization of some excipients. Formulation B, containing glycine, was the most crystalline one. It also revealed higher stability. Due to the presence of dextran, formulation A was less crystalline than B. The decrease in human alpha interferon stability could be ascribed to the formulation's high salt content.

Details

  • Original title: Effect of formulation on stability of freeze-dried recombinant human alpha interferon.
  • Record ID : 1996-2573
  • Languages: English
  • Source: Cryo-Letters - vol. 16 - n. 5
  • Publication date: 1995/09
  • Document available for consultation in the library of the IIR headquarters only.

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