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Effects of cryopreservation on immune responses.

Author(s) : VENKATARAMAN M.

Type of article: Article

Summary

The effect of freezing on phytohemagglutinin-induced interferon-gamma (IFN-gamma) production by human peripheral blood mononuclear cells (PBMCs) was studied. The possible mechanisms responsible for the observed effects were also analysed. Frozen PBMCs produced significantly larger quantities of IFN-gamma than fresh cells. The results suggest that functional inactivation of a subset of cryosensitive suppressor monocytes is associated with an increase in IFN-gamma production by the T lymphocytes. The results provide further evidence that monocytes mediate their suppressive effect through the activation of a subset of radiosensitive, immuno-down-regulatory T cells.

Details

  • Original title: Effects of cryopreservation on immune responses.
  • Record ID : 1996-2563
  • Languages: English
  • Source: Cryobiology - vol. 32 - n. 6
  • Publication date: 1995/12

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