Effects of cryopreservation on immune responses: decrease in interleukin-12 production by frozen human peripheral blood mononuclear cells is mediated by the endogenously hypersecreted interleukin-10. Part 10.

Type of article: Article

Summary

Considering the pivotal role played by interleukin-12 (IL-12) in the immune system, and in antimicrobial and antitumor activities, production of only 10% of the normal levels by the frozen cells could have profound impact on patients receiving such frozen peripheral blood mononuclear cells (PMBCs) as stem cell support following myeloablative therapy. Administration of exogenous IL-12 at the time of frozen PMBC transplantations might have a therapeutic value in these patients.

Details

Original title: Effects of cryopreservation on immune responses: decrease in interleukin-12 production by frozen human peripheral blood mononuclear cells is mediated by the endogenously hypersecreted interleukin-10. Part 10.
Record ID : 1997-2476
Languages: English
Source: Cryobiology - vol. 33 - n. 5
Publication date: 1996/10

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Indexing

Themes: The influence of refrigeration on cells, tissues and organs
Keywords: Leucocyte; Blood; Immunology; Man; Cryopreservation