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Effects of different cold preservation solutions on restoration of hepatic energy metabolism during cold reperfusion.

Author(s) : MITCHELL S. J., CHURCHILL T. A., WINSLET M. C., FULLER B. J.

Type of article: Article

Summary

Rat livers were flushed with different preservation solutions and stored at 4 deg C for 24 hours before being reperfused with a synthetic air-equilibrated water-based solution. Four solutions were tested using this isolated rat liver model: Marshall's hypertonic citrate; modified University of Wisconsin solution (UW); a histidine-based solution; a histidine-lactobionate-raffinose-based solution (HLR). The solutions providing the better preservation conditions gave the greater resuscitation of liver energetics (UW and HLR). Overall, livers stored in HLR had the greatest resuscitation of energy metabolism, which correlates with survival data from other studies.

Details

  • Original title: Effects of different cold preservation solutions on restoration of hepatic energy metabolism during cold reperfusion.
  • Record ID : 1997-1140
  • Languages: English
  • Source: Cryobiology - vol. 33 - n. 4
  • Publication date: 1996/08

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