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Evolution of an antifreeze glycoprotein.

Author(s) : CHENG C. H., CHEN L.

Type of article: Article

Summary

The ice-binding anti-freeze glycoprotein (AFGP) that circulates in the blood of Antarctic notothenioid fishes enables them to avoid freezing in their perpetually icy environment. This crucial survival protein probably arose from a functionally unrelated pancreatic trypsinogen-like protease. The authors have discovered an important intermediate in this evolutionary process: transcriptionally active chimaeric genes that encode both an AFGP polyprotein and the protease, confirming the protease origin of AFGP and indicating how it was created.

Details

  • Original title: Evolution of an antifreeze glycoprotein.
  • Record ID : 2000-0437
  • Languages: English
  • Source: Nature - vol. 401 - n. 6752
  • Publication date: 1999/09/30
  • Document available for consultation in the library of the IIR headquarters only.

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