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FREEZE-FRACTURE AND MICROVISCOSITY OF LYMPHOCYTE MEMBRANES IN MYASTHENIA GRAVIS.

Author(s) : SHIMIZU Y.

Type of article: Article

Summary

ALTERATIONS OF MEMBRANE SURFACE AND MEMBRANE MICROVISCOSITY WERE STUDIED IN PERIPHERAL BLOOD LYMPHOCYTES FROM MYASTHENIC PATIENTS AND COMPARED WITH THOSE FROM HEALTY SUBJECTS AND SLE (SYSTEMIC LUPUS ERYTHEMATOSUS) PATIENTS. THE MEMBRANE ULTRAMICROSTRUCTURE OF MYASTHENIC LYMPHOCYTES WAS CHANGED LESS THAN THOSE OF HEALTHY AND SLE LYMPHOCYTES. IT SHOWED SLIGHTLY CLUSTERED MAP (MEMBRANE ASSOCIATED PARTICLES) WITH LARGER DIAMETERS AND LESS DENSITY THAN THE HEALTHY LYMPHOCYTES AND WITH LESS PROMINENT WAVY SURFACES THAN SLE LYMPHOCYTES. THE MICROVISCOSITY OF THE MYASTHENIC LYMPHOCYTES WAS SIGNIFICANTLY LOWER THAN THAT OF THE HEALTHY CONTROLS AND CORRELATED WELL WITH CLINICAL SEVERITY AND THE TITERS OF ANTI-ACHR (ANTIACETYLCHOLINE RECEPTORS) ANTIBODY AND T CELL MEMBRANE BINDING ANTIBODY. CON A (CONCANAVALLIN A) AHLA (ANTI HUMAN LYMPHOCYTE ANTIBODY), AND MYASTHENIC SERA REDUCED THE MICROVISCOSITIES OF THE HEALTHY LYMPHOCYTES. HOCYTE SURFACE WERE REFLECTED IN THE ALTERATION OF MICROVISCOSITY OF LYMPHOCYTES THROUGH THE INTERACTION BETWEEN SURFACE RECEPTORS OF T LYMPHOCYTES AND ANTI-MEMBRANE ANTIBODY, ESPECIALLY ANTI-ACHR ANTIBODY AND T CELL MEMBRANE BINDING IN PATIENTS WITH MYASTHENIA GRAVIS.

Details

  • Original title: FREEZE-FRACTURE AND MICROVISCOSITY OF LYMPHOCYTE MEMBRANES IN MYASTHENIA GRAVIS.
  • Record ID : 1981-1364
  • Languages: English
  • Source: Tokai J. exp. clin. Med. - vol. 5 - n. 2
  • Publication date: 1980
  • Document available for consultation in the library of the IIR headquarters only.

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