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INCREASED CIRCULATING BRADYKININ DURING HYPOTHERMIA AND CARDIOPULMONARY BYPASS IN CHILDREN.

Author(s) : MEI PANG L.

Type of article: Article

Summary

TO DETERMINE WHETHER COLD COULD ACTIVATE THE KALLIKREIN-KININ SYSTEM IN VIVO AS IT DOES IN VITRO, THE CIRCULATING SYSTEMIC CONCENTRATIONS OF BRADYKININ WERE SERIALLY MEASURED IN 10 CHILDREN WITH CONGENITAL DISEASES OF THE HEART UNDERGOING CORRECTIVE CARDIAC SURGERY. THE CIRCULATING CONCENTRATIONS OF BRADYKININ INCREASED SIGNIFICANTLY AS BODY TEMPERATURE DECREASED DURING SURFACE COOLING. WITH THE ONSET OF CARDIOPULMONARY BYPASS AND HENCE, REMOVAL OF THE LUNG AND PULMONARY CONVERTING ENZYME FROM THE CIRCULATION, THERE WAS A FURTHER RISE IN THE ALREADY ELEVATED CONCENTRATIONS OF BRADYKININ. THIS IS THE FIRST IN VIVO DEMONSTRATION THAT HYPOTHERMIA LEADS TO AN INCREASE IN THE CIRCULATING CONCENTRATIONS OF BRADYKININ.

Details

  • Original title: INCREASED CIRCULATING BRADYKININ DURING HYPOTHERMIA AND CARDIOPULMONARY BYPASS IN CHILDREN.
  • Record ID : 1981-0323
  • Languages: English
  • Source: Circulation - vol. 60 - n. 7
  • Publication date: 1979/12
  • Document available for consultation in the library of the IIR headquarters only.

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