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Influence of freezing process on pore structure of freeze-dried collagen sponges.

Einfluss des Einfriervorganges auf die Porenstruktur gefriergetrokneter Kollagenschwämme.

Author(s) : SCHOOF H., BRUNS L., APEL J., HESCHEL I., RAU G.

Type of article: Article

Summary

Freeze-dried collagen sponges are used as biodegradable connective tissue implants. The microstructure of the pores in the collagen sponges is extremely important for the migration of cells. Since the porous structure after freeze-drying corresponds to the ice crystal morphology, the microstructure mainly depends on the freezing process applied. In industrial production processes the collagen suspension is commonly frozen in a tray that is immersed in a cryogenic bath. Freezing conditions vary within such a sample resulting in an inhomogeneous pore structure. In contrast, by using directional solidification, collagen sponges with a homogeneous and adjustable microstructure can be produced.

Details

  • Original title: Einfluss des Einfriervorganges auf die Porenstruktur gefriergetrokneter Kollagenschwämme.
  • Record ID : 1999-1937
  • Languages: German
  • Source: KI Luft Kältetech. - vol. 34 - n. 5
  • Publication date: 1998/05
  • Document available for consultation in the library of the IIR headquarters only.

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