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Insights on the tightness and long-term storage suitability of cryovials and straws in biobanking.

Number: 0029

Author(s) : KRETSCHMER R., REINSCH H., KADE A.

Summary

The long-time storage of biological specimen is very important for biomedical research, e.g. for the investigation of common diseases. Since many research activities are based on such samples, their integrity is a critical task. Under common storage conditions biodegradation processes are slowed, but low temperatures also pose risks to the sample by material fatigue of the storage container with increasing storage time. This can result in leaks, which can lead to contamination or to chemical reactions (e.g. oxidation).
The CO2 leak test enables a statement on the risk of contamination during transportation on dry ice. The LN2 leak test differentiates between temporary and permanent leakage after LN2 contact. Furthermore the tightness under both conditions, at negative pressure and at temperatures from −40 °C to +55 °C, is evaluated. In order to characterize the storage stability, tensile tests and DSC measurements of fresh, real-time stored and cyclically thermal stressed packaging materials are compared. The objective is a simulation of long-term storage by cyclical alternating loads and to evaluate the impact on the integrity of the vials.

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Pages: 7

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Details

  • Original title: Insights on the tightness and long-term storage suitability of cryovials and straws in biobanking.
  • Record ID : 30029020
  • Languages: English
  • Source: Cryogenics 2021 online. Proceedings of the 16th IIR International Conference, October 5-7, 2021.
  • Publication date: 2021/10/05
  • DOI: http://dx.doi.org/10.18462/iir.cryo.2021.0029
  • Document available for consultation in the library of the IIR headquarters only.

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