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Metabolic adaptations of a lower vertebrate to long-term hypothermic hypoxia provide clues to successful clinical liver preservation.

Author(s) : CHURCHILL T. A., FEDOROW C. A., KNETEMAN N. M.

Type of article: Article

Summary

This study was designed to determine whether the metabolic adaptations developed by frogs to tolerate natural events of hypothermic hypoxia would precondition its liver for ex vivo organ storage. With respect to clinical relevance, the results of this study indicate that energetics of stored livers can be maintained effectively through an efficient reduction in energy use in combination with a slow, yet continuous, rate of energy production facilitated by glycolysis.

Details

  • Original title: Metabolic adaptations of a lower vertebrate to long-term hypothermic hypoxia provide clues to successful clinical liver preservation.
  • Record ID : 1999-1230
  • Languages: English
  • Source: Cryobiology - vol. 36 - n. 2
  • Publication date: 1998/03

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