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MORPHOLOGIC AND FUNCTIONAL EFFECTS OF RENAL CRYOINJURY.

Author(s) : BARONE G. W., RODGERS B. M.

Type of article: Article

Summary

THE STUDY WAS DESIGNED TO EXAMINE THE EFFECTS OF PROFOUND CRYOTHERAPY ON A SIGNIFICANT PORTION OF THE RENAL PARENCHYMA, SIMULATING THE CLINICAL APPLICATION OF THIS TECHNIQUE. THE CONTRALATERAL KIDNEY IN THE EXPERIMENTAL ANIMALS WAS SUBJECTED TO CRYOINJURY WITH A LIQUID NITROGEN PROBE. THE KIDNEY WAS COOLED UNTIL THE < CORE > TEMPERATURE REACHED 233 K (-40 DEG C). TRANSIENT GROSS HEMATURIA WAS NOTED IN 25% OF THE ANIMALS AND MICROSCOPIC HEMATURIA IN 50%. SERUM BLOOD UREA NITROGEN AND CREATININE LEVELS REACHED MAXIMUM LEVELS AT 72 HOURS AND GRADUALLY RETURNED TOWARD NORMAL THEREAFTER. THE CRYOLESION AT 24 HOURS RESEMBLED A HEMORRHAGIC INFARCT INVOLVING 40% OF THE KIDNEY. BY 8 WEEKS THIS LESION HAD CONTRACTED TO A FIBROTIC LESION INVOLVING 20% OF THE KIDNEY BY WEIGHT.

Details

  • Original title: MORPHOLOGIC AND FUNCTIONAL EFFECTS OF RENAL CRYOINJURY.
  • Record ID : 1989-2084
  • Languages: English
  • Source: Cryobiology - vol. 25 - n. 4
  • Publication date: 1988

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