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SELENO-DL-METHIONINE REDUCES FREEZING INJURY IN HEARTS PROTECTED WITH ETHANEDIOL.

Author(s) : ARMITAGE W. J., MATTHES G., PEGG D. E.

Type of article: Article

Summary

PERFUSION OF WHOLE RABBIT HEARTS WITH SOLUTIONS CONTAINING 20 M/LITER SELENO-DL-METHIONINE IMPROVED THE CRYOPROTECTION AFFORDED BY ETHANEDIOL (3 MOL/LITER) DURING FREEZING AT 258K (-15 DEG C). IN FIVE OF THE SIX HEARTS FROZEN WITH SELENO-DL-METHIONINE, ALL OF THE CHAMBERS CONTRACTED AFTER REWARMING AND REMOVAL OF ETHANEDIOL, WHEREAS IN HEARTS FROZEN WITHOUT SELENIUM, ONLY ONE OR TWO CHAMBERS SHOWED ANY ACTIVITY. THE VASCULAR RESISTANCE IN HEARTS FROM BOTH GROUPS INCREASED APPROXIMATELY SIXFOLD DURING THE REMOVAL OF THE CRYOPROTECTANT, INDICATING SEVERE VASCULAR DAMAGE. ALTHOUGH VASCULAR DAMAGE WAS SEVERE, SELENIUM APPARENTLY INCREASED THE TOLERANCE OF THE MYOCARDIAL CELLS TO FREEZING.

Details

  • Original title: SELENO-DL-METHIONINE REDUCES FREEZING INJURY IN HEARTS PROTECTED WITH ETHANEDIOL.
  • Record ID : 1982-1044
  • Languages: English
  • Source: Cryobiology - vol. 18 - n. 4
  • Publication date: 1981/08

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