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THE EFFECTS OF PLASTICIZER IN CONTAINERS USED FOR RED CELL PRESERVATION AT 273 K (0 DEG C).

[In Japanese. / En japonais.]

Author(s) : YAMAMURA H.

Type of article: Article

Summary

THE AUTHORS HAVE RECENTLY SHOWN THAT RED BLOOD CELLS CAN BE BETTER STORED AT 273 K (0 DEG C) THAN AT 278 K (5 DEG C). HOWEVER, THIS FINDING CONFLICTS WITH PREVIOUS REPORTS THAT STORAGE BELOW 278 K LEADS TO THE DETERIORATION OF RED CELLS. TO CLARIFY THIS DISCREPANCY, THEY STUDIED THE EFFECTS OF DIFFERENT BLOOD CONTAINERS ON RED CELL PRESERVATION AT ABOUT 273 K. THE RED CELLS STORED WITH A PVC BAG CONTAINING DI(2-ETHYLHEXYL) PHTHALATE (DEHP) AS A PLASTICIZER SHOWED MUCH LOWER HEMOLYSIS AND HIGHER LEVELS OF MORPHOLOGYTHAN THOSE STORED WITH A GLASS BOTTLE. THESE DATA INDICATE THAT THE DEHP LEACHED FROM THE PVC BAG HAD A MARKED PROTECTIVE EFFECT AGAINST INJURY OF RED CELLS AT LOW TEMPERATURE. THEREFORE, THE STORAGE TEMPERATURE OF RED CELLS CAN BE LOWERED TO ABOUT 273 K WHEN A DEHP-PVC BAG IS USED AS THE CONTAINER.

Details

  • Original title: [In Japanese. / En japonais.]
  • Record ID : 1991-2784
  • Languages: Japanese
  • Source: Low Temperature Medicine - vol. 17 - n. 1
  • Publication date: 1991/03
  • Document available for consultation in the library of the IIR headquarters only.

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