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The evaluation of N-modified betaines as erythrocyte cryoprotectants.

Author(s) : LLOYD A. W., BAKER J. A., OLLIFF C. J., RUTT K. J.

Type of article: Article

Summary

The ability of a series of N-modified betaines to reduce haemolysis of erythrocytes on freeze-thaw has been compared to that of glycin, sarcosin, N-dimethylglycin and glycin betaine. Increasing the alkylation of the nitrogen improves the optimum protection offered by these compounds. Glycinebetaine has also been shown to potentiate the effects of DMSO at low additive concentrations.

Details

  • Original title: The evaluation of N-modified betaines as erythrocyte cryoprotectants.
  • Record ID : 1994-1269
  • Languages: English
  • Source: Cryo-Letters - vol. 13 - n. 5
  • Publication date: 1992/09
  • Document available for consultation in the library of the IIR headquarters only.

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