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THE MECHANISM OF STRUCTURAL AND OSMOTIC ADAPTATION OF ERYTHROCYTES TO CRYOPRESERVATION.

Author(s) : BABIYCHUK L. A., ZEMLYANSKIKH N. G.

Summary

THE AUTHORS FOUND IN THEIR EXPERIMENTS THAT STEPWISE COLD TREATMENT OF ERYTHROCYTES WITH AN IMPERMEABLE CRYOPROTECTANT POLYETHYLENE OXIDE OF MOLECULAR WEIGHT 1500 (PEO-1500) FAVOURS THE DEVELOPMENT OF INCREASED CELL RESISTANCE TO SUBSEQUENT FREEZE-THAWING. THIS CAN BE SEEN IN A SHARP DECREASE OF HEMOLYSIS AND OSMOTIC FRAGILITY OF ERYTHROCYTES AFTER TRANSFER TO MEDIA OF PHYSIOLOGICAL TONICITY, WHEN COMPARED TO CELLS TREATED AT ROOM TEMPERATURE.

Details

  • Original title: THE MECHANISM OF STRUCTURAL AND OSMOTIC ADAPTATION OF ERYTHROCYTES TO CRYOPRESERVATION.
  • Record ID : 1990-2145
  • Languages: English
  • Publication date: 1989/07/06
  • Source: Source: Proc. IVth int. Sch. Cryobiol. Freeze-drying, Borovets
    L31-L33; 4 fig.; 1 tabl.
  • Document available for consultation in the library of the IIR headquarters only.

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