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Thyroid cryotherapy in an experimental rat model.

Author(s) : POMORSKI L., BARTOS M., MATEJKOWSKA M., et al.

Type of article: Article

Summary

In recent years, cryotherapy has been more and more frequently used for the treatment of tumours of different organs. Until now, the use of cryotherapy for the treatment of thyroid lesions, as well as histopathologic changes in thyroid tissue after cryotherapy, has not been described. The macroscopic evaluation, performed 2 and 4 weeks postcryotherapy, revealed atrophy of the cryotreated lobe in 4 and 3 rats, respectively, and reduction of the cryotreated lobe dimensions in 6 and 7 rats, respectively. In specimens of the lobes excised 2 weeks following cryotherapy, examined microscopically, necrosis, granulomatous inflammation, hemorrhages, and hemosiderin deposits were found most often, whereas in the specimens of the lobe excised after 4 weeks lymphocytic inflammation and fibrosis were mainly observed. There was no microscopic damage to other tissues adjacent to the thyroid. No rat developed vocal cord dysfunction after cryotherapy and no significant changes in serum calcium level before and after cryotherapy were observed. Results obtained show that it is possible to cryoblate thyroid tissue without damaging the tissues adjacent to the thyroid, as well as to spare function of the recurrent laryngeal nerves and parathyroid glands.

Details

  • Original title: Thyroid cryotherapy in an experimental rat model.
  • Record ID : 2001-0553
  • Languages: English
  • Source: Cryobiology - vol. 39 - n. 3
  • Publication date: 1999/11

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