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Ultrastructural and metabolic effects after vitrification of precision-cut rat liver slices with antifreeze proteins.

Author(s) : EKINS S., MURRAY G. I., HAWKSWORTH G. M.

Type of article: Article

Summary

The work has shown that antifreeze protein I increases conjugation activity and therefore may be useful as a protectant against loss of cytosolic enzymes. In conclusion, antifreeze proteins may be useful as cryoprotectants for tissue slice vitrification and long term storage, which could be applicable to liver or tissues from other species, in particular man. However, this method requires optimisation for the preservation of rat liver slices, to maintain xenobiotic phase I and II metabolism.

Details

  • Original title: Ultrastructural and metabolic effects after vitrification of precision-cut rat liver slices with antifreeze proteins.
  • Record ID : 1997-1145
  • Languages: English
  • Source: Cryo-Letters - vol. 17 - n. 3
  • Publication date: 1996/05
  • Document available for consultation in the library of the IIR headquarters only.

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