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Applications for cryopreserved blood vessels in pharmacological research.

Author(s) : MULLER-SCHWEINITZER E.

Type of article: Article

Summary

Cryopreservation of isolated blood vessels at -70 to -196 deg C in a medium containing du DMSO offers the prospect of virtually infinite storage of the material with the only damage being that associated with the freezing and thawing process. Despite certain changes, such as reductions in contractile forces and endothelial functions, the main biochemical properties, uptake mechanisms, and affinities of most agonists and antagonists have been shown to be well preserved after cryopreservation. Hence, this technique offers clear potential for ensuring the supply of vascular material for pharmacological studies.

Details

  • Original title: Applications for cryopreserved blood vessels in pharmacological research.
  • Record ID : 1995-1226
  • Languages: English
  • Source: Cryobiology - vol. 31 - n. 1
  • Publication date: 1994/02

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