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BASIC STUDIES OF CRYOCHEMOTHERAPY IN A MURINE TUMOUR SYSTEM.

Author(s) : IKEKAWA S.

Type of article: Article

Summary

THE COMBINED EFFECT OF CRYOSURGERY AND ANTICANCER DRUGS (CRYOCHEMOTHERAPY) WAS STUDIED IN AN EXPERIMENTAL B16 MELANOMA/BDF, TUMOUR SYSTEM. THE VASCULAR VOLUME AND VASCULAR PERMEABILITY OF BOTH THE NORMAL VESSELS AND THE TUMOUR VESSELS GREATLY INCREASED IMMEDIATELY AFTER CRYOSURGERY, AND THEIR VASCULAR VOLUME DECREASED TO LESS THAN THE NORMAL LEVEL WITHIN A FEW HOURS. WHEN PEPLOMYCIN WAS ADMINISTERED 5 MIN, 1 HR, AND 3 HR AFTER CRYOSURGERY, THE DRUG CONCENTRATION IN THE FROZEN TUMOUR WAS HIGHER THAN THAT IN THE UNTREATED TUMOUR. BUT WHEN ADMINISTERED 1 HR BEFORE CRYOSURGERY, PEPLOMYCIN WAS NOT TRAPPED IN THE TUMOUR. IT IS NECESSARY TO ADMINISTER THE APPROPRIATE DRUG AT THE APPROPRIATE TIME. THE TRAPPING OF THE ANTICANCER DRUG RESULTS IN A HIGH CONCENTRATION AND LASTS FOR A LONG TIME, SO THAT CRYOCHEMOTHERAPY IS EXPECTED TO BE A NEW MODE OF CANCER THERAPY.

Details

  • Original title: BASIC STUDIES OF CRYOCHEMOTHERAPY IN A MURINE TUMOUR SYSTEM.
  • Record ID : 1986-2113
  • Languages: English
  • Source: Cryobiology - vol. 22 - n. 5
  • Publication date: 1985

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