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CRYOPRESERVATION OF HEMOPOIETIC TISSUE AIMED AT REDUCING IMMUNOLOGICAL REACTIVITY.

Author(s) : FEDOTENKOV A. G., IGNASHOVA L. P., DANYLOVA I. A.

Type of article: Article

Summary

A METHOD HAS BEEN DEVELOPED OF DECREASING IMMUNOLOGIC ACTIVITY OF LYMPHOCYTES FROM SPLEEN, LYMPH NODES, AND BONE MARROW (FRESHLY COLLECTED OR FROZEN). IN EXPERIMENTS IN VIVO ON LETHALLY IRRADIATED MICE, IT WAS DEMONSTRATED THAT DURING COMBINED TRANSPLANTATION TO THE RECIPIENTS OF PRESERVED BONE MARROW FROM TWO GENETICALLY DIFFERENT DONORS, A RAPID DECREASE OR ABSENCE OF THE EFFECT OF INACTIVATION OF HEMOPOIETIC STEM CELLS UNDER THE INFLUENCE OF ALLOGENEIC LYMPHOCYTES WAS OBSERVED IN THE MIXED GRAFT. TO TRANSPLANT LARGE QUANTITIES OF BONE MARROW FROM SEVERAL GENETICALLY DIFFERENT DONORS, THE USE OF CRYOPRESERVED BONE MARROW IS PREFERABLE TO FRESHLY DRAWN MARROW.

Details

  • Original title: CRYOPRESERVATION OF HEMOPOIETIC TISSUE AIMED AT REDUCING IMMUNOLOGICAL REACTIVITY.
  • Record ID : 1986-2544
  • Languages: English
  • Source: Cryobiology - vol. 23 - n. 1
  • Publication date: 1986

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