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Impact of thermal properties on protein formulation and freeze-drying development.

Author(s) : PASSOT S., FONSECA F., MARIN M.

Summary

Freeze-drying continues to increase in importance due to the widespread development of protein therapeutic agents. This results in a great interest in analytical approaches to formulation and process development based on a better understanding of the physical chemistry of freezing and freeze-drying. This article describes how two analytical methods, differential scanning calorimetry and freeze-drying microscopy can help the formulation scientist to develop the optimum freeze-dried protein formulation allowing the most efficient freeze-drying process.

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Pages: 2007-3

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Details

  • Original title: Impact of thermal properties on protein formulation and freeze-drying development.
  • Record ID : 2008-2761
  • Languages: English
  • Source: New Ventures in Freeze-Drying
  • Publication date: 2007/07

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