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Impact of thermal properties on protein formulation and freeze-drying development.

Impacto de las propiedades térmicas en la formulación de proteínas y el desarrollo de la liofilización.

Author(s) : PASSOT S., FONSECA F., MARIN M.

Type of article: Article

Summary

This article is the Spanish translation of an article presented at the IIR conference in Strasbourg, France (see the Bulletin of the IIR, reference 2008-2761). Freeze-drying continues to increase in importance due to the widespread development of protein therapeutic agents. This results in a great interest in analytical approaches to formulation and process development based on a better understanding of the physical chemistry of freezing and freeze-drying. This article describes how two analytical methods, differential scanning calorimetry and freeze-drying microscopy can help the formulation scientist to develop the optimum freeze-dried protein formulation allowing the most efficient freeze-drying process.

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Pages: pp. 24-32 (8 p.)

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Details

  • Original title: Impacto de las propiedades térmicas en la formulación de proteínas y el desarrollo de la liofilización.
  • Record ID : 2010-0959
  • Languages: Spanish
  • Source: IIF-IIR/Frío Calor Aire acond. - vol. 37 - n. 417
  • Publication date: 2009/09

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