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INTERVIAL VARIANCE OF THE SUBLIMATION RATE IN SHELF FREEZE-DRIER.

Author(s) : KOBAYASHI M., et al.

Summary

IN THE SHELF FREEZE-DRYING OF PHARMACEUTICALS, ONE OF THE IMPORTANT PROBLEMS IS TO REALIZE INTERVIAL UNIFORMITY AND BATCH TO BATCH UNIFORMITY OR CONSISTENCY. THE PAPER DISCUSSES A METHOD FOR ELIMINATING INTERVIAL VARIANCE IN THE DRYING CONDITIONS AND TO SHORTEN THE DRYING TIME. AUTHORS HAVE DEVELOPED A NEW MODEL OF LAB-SCALE PILOT FREEZE-DRIERWITH TEMPERATURE CONTROLLABLE CHAMBER WALLS WHICH MUST BE A LITTLE LOWER THAN THE MATERIAL TEMPERATURE.

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Pages: 1711-1715

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Details

  • Original title: INTERVIAL VARIANCE OF THE SUBLIMATION RATE IN SHELF FREEZE-DRIER.
  • Record ID : 1992-2493
  • Languages: English
  • Source: New challenges in refrigeration. Proceedings of the XVIIIth International Congress of Refrigeration, August 10-17, 1991, Montreal, Quebec, Canada.
  • Publication date: 1991/08/10
  • Document available for consultation in the library of the IIR headquarters only.

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