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THERMAL SHOCK HEMOLYSIS IN HUMAN RED CELLS. 1. THE EFFECTS OF TEMPERATURE, TIME AND OSMOTIC STRESS.

Author(s) : TAKAHASHI T., WILLIAMS R. J.

Type of article: Article

Summary

THERMAL SHOCK IS A FORM OF HEMOLYSIS WHICH OCCURS IN HUMAN RED CELLS EXPOSED TO GREATER THAN A CRITICAL LEVEL OF OSMOTIC STRESS OF 1.4 OSM AND SUBSEQUENTLY COOLED FROM ABOVE ABOUT 285 K (12 DEG C) TO BELOW THAT TEMPERATURE. HIGHER CONCENTRATIONS AND HIGHER COOLING RATES EACH INCREASE THE AMOUNT OF HEMOLYSIS, WITHIN LIMITS. THE EFFECT OF COOLING RATE ON THERMAL SHOCK IS INDEPENDENT OF THE PERIOD OF EXPOSURE TO HYPERTONIC SOLUTIONS. THERMAL SHOCK IS NOT THE CAUSE OF FREEZING INJURY AT LEAST ABOVE 263 K (-10 DEG C).

Details

  • Original title: THERMAL SHOCK HEMOLYSIS IN HUMAN RED CELLS. 1. THE EFFECTS OF TEMPERATURE, TIME AND OSMOTIC STRESS.
  • Record ID : 1984-1244
  • Languages: English
  • Source: Cryobiology - vol. 20 - n. 5
  • Publication date: 1983

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