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IIR document

Welded cryovials – a contribution to minimize contamination.

Number: 0005

Author(s) : MIKSCHE R., KRETSCHMER R., KADE A.

Summary

The tightness of cryovials is a quality feature for the long term storage of biological samples. Because of detected leakages on the cryovials after simulating the transport on dry ice and storage in LN2, the necessity to improve the tightness was requested. This led to the development of a new cryovial, which is tight from −196 °C to +55 °C. To achieve this, cryotube and cap should be welded together. A prototype of a welding tool was designed, built and tested. The welding tool melts the thermoplastic material of tube and cap reliably and reproducibly. Loosening of the cap is possible with a tool. The three different test methods gravimetric leakage test, CO2-test and LN2-test were utilized to evaluate the tightness of the new welded cryovial. The results show that all welded cryovials pass the gravimetric leakage test and CO2-test. The leakage after contact with LN2 can be drastically reduced.

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Pages: 6 p.

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Details

  • Original title: Welded cryovials – a contribution to minimize contamination.
  • Record ID : 30033868
  • Languages: English
  • Subject: Technology
  • Source: Cryogenics 2025. Proceedings of the 18th IIR International Conference on Cryogenics, Prague, Czech Republic, 7-11 April 2025.
  • Publication date: 2025/04/07
  • DOI: http://dx.doi.org/10.18462/iir.cryo.2025.0005

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