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The application of analytical methods and model systems in the lyophilization of complex biomolecules.

Liofilización de biomoléculas complejas: aplicación de métodos analíticos y sistemas de modelo.

Author(s) : MATEJTSCHUK P., MALIK K. P., DURU C., et al.

Type of excerpt: Other

Summary

This article is the Spanish translation of an article presented at the IIR meeting in Strasbourg, France (see the Bulletin of the IIR, reference 2008-2754). NIBSC produces primary biological reference materials from a wide range of sources, including sera, cell culture, purified proteins, nucleic acids and carbohydrates, and from complex preparations including viral lysates and cellular materials. Most of these standards are lyophilized to provide assured stability over a shelf life of many years. Many of these preparations have multi-component formulations and over recent years, the authors have applied a wide range of analytical methods to determine the critical thermal transitions and eutectic properties. Low residual moisture and controlled container properties are also essential to maintain this prolonged storage stability and the authors' experiences in these areas is shared. The presentation is illustrated by reference to both model systems and processed standards which have enabled them to arrive at a rational approach to the challenges of manufacturing such a wide range of lyophilized reference materials.

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Format PDF

Pages: 24-31

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Details

  • Original title: Liofilización de biomoléculas complejas: aplicación de métodos analíticos y sistemas de modelo.
  • Record ID : 2009-1341
  • Languages: Spanish
  • Publication date: N/A
  • Source: Source: IIF-IIR/Frío Calor Aire acond.
    vol. 37; n. 413; 24-31; fig.; tabl.; 8 ref.

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