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A morphological study of cooling rate response in normal and neoplastic human liver tissue: cryosurgical implications.

Author(s) : BISCHOF J., CHRISTOV K., RUBINSKY B.

Type of article: Article

Summary

The process of freezing in normal human livers and in human liver tumors was studied by freezing samples of these tissues with constant cooling rates and then examining the morphology of the frozen tissue, after freeze substitution, with the light microscope. Cooling rates varied from 2 deg C/min up to approximately 2,000 deg C/min. It was observed that high cooling rates produce extensive intracellular ice in both normal and neoplastic liver. At slow rates of cooling, normal and neoplastic liver cells dehydrated and large extracellular ice crytals formed. These results suggest that malignant tissues have a different response to freezing than normal tissues.

Details

  • Original title: A morphological study of cooling rate response in normal and neoplastic human liver tissue: cryosurgical implications.
  • Record ID : 1994-1904
  • Languages: English
  • Source: Cryobiology - vol. 30 - n. 5
  • Publication date: 1993/10

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